Issue 95, 2015
From the journal:

RSC Advances

Chemoselective calcium-catalysed direct amidation of carboxylic esters†

D. Thao Nguyen,a   Danny C. Lenstraa  and  Jasmin Mecinović*a  

* Corresponding authors

a Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
E-mail: j.mecinovic@science.ru.nl

Abstract

Unactivated carboxylic esters and primary amines undergo calcium-catalysed direct amide bond formation in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

Graphical abstract: Chemoselective calcium-catalysed direct amidation of carboxylic esters

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Article information

DOI
https://doi.org/10.1039/C5RA18288C
Article type
Communication
Submitted
16 Jul 2015
Accepted
09 Sep 2015
First published
09 Sep 2015

RSC Adv., 2015,5, 77658-77661

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Chemoselective calcium-catalysed direct amidation of carboxylic esters

D. T. Nguyen, D. C. Lenstra and J. Mecinović, RSC Adv., 2015, 5, 77658 DOI: 10.1039/C5RA18288C

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