Issue 2, 2016

Cyclic RGD targeting cisplatin micelles for near-infrared imaging-guided chemotherapy

Abstract

Nowadays imaging-guided chemotherapy is of great importance for developing highly efficient nanomedicines for cancer therapy. However, drug accumulation and release in vivo cannot be tracked in most studies due to the imaging moiety. In this study, near-infrared (NIR) dyes, cisplatin and dextran were used to prepare an imaging-guided chemotherapy drug with a cyclic peptide arginine-glycine-aspartic acid (RGD) targeting property for the treatment of breast cancer. Confocal laser scanning microscopy (CLSM) analysis indicated that the cisplatin-loaded micelles with cRGD decoration were quickly taken up by breast cancers cells in vitro according to the fluorescence of the NIR dye. More importantly, in vivo bioluminescence imaging analysis indicated that the drug-loaded micelles were preferentially distributed in the tumor regions of tumor-bearing mice. Furthermore, combining RGD targeting, in vivo imaging and therapeutic properties, this nanomedicine was suggested to have a good anti-tumor activity in vivo. Our study highlights the potential of combining active targeting and NIR fluorescence imaging in one drug delivery system for cancer diagnosis and therapy.

Graphical abstract: Cyclic RGD targeting cisplatin micelles for near-infrared imaging-guided chemotherapy

Article information

Article type
Paper
Submitted
24 Sep 2015
Accepted
19 Nov 2015
First published
01 Dec 2015

RSC Adv., 2016,6, 1151-1157

Author version available

Cyclic RGD targeting cisplatin micelles for near-infrared imaging-guided chemotherapy

X. Guan, X. Hu, S. Liu, X. Sun and X. Gai, RSC Adv., 2016, 6, 1151 DOI: 10.1039/C5RA19711B

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