Issue 125, 2015

Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp3)–H functionalization of 2-alkylazaarenes

Abstract

A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the direct Michael addition/C(sp3)–H functionalization of 2-alkylazaarenes with aldehydes and ketones via an aldol reaction has been developed. This is the first report and provides cost effective new access to potent biologically/medicinally important azaarene derivatives with high atom economy.

Graphical abstract: Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp3)–H functionalization of 2-alkylazaarenes

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2015
Accepted
18 Nov 2015
First published
19 Nov 2015

RSC Adv., 2015,5, 103091-103094

Author version available

Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp3)–H functionalization of 2-alkylazaarenes

S. S. Chavan, M. Y. Pathan and S. A. R. Mulla, RSC Adv., 2015, 5, 103091 DOI: 10.1039/C5RA20728B

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