Synthesis of substituted pyrroles using a silver-catalysed reaction between isocyanoacetates/benzyl isocyanides and chromones

Abstract

A novel synthetic strategy to construct substituted-pyrroles has been developed using silver-catalysed reactions between isocyanides/benzyl isocyanides and chromones. These reactions proceed under mild conditions and yield polysubstituted pyrroles with efficient yields. The silver catalyst plays a key role in sequestering and activating the isocyano group and in sequential Michael addition and cyclization reactions.