Microwave-assisted regioselective sulfenylation of indoles under solvent- and metal-free conditions

Abstract

Herein, we report a solvent- and metal-free methodology for the sulfenylation of indoles with sulfinic acids in the absence of an external catalyst under microwave irradiation. This environmentally friendly approach offered the desired products in moderate to excellent yields in only 10 min. Several functional group tolerances were monitored under the optimized conditions.