Issue 31, 2016

Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states

Abstract

Sulfamethazine (SMT), a widely used antibacterial drug, can form either a 1 : 1 salt or a 1 : 1 cocrystal with saccharin (SAC), an artificial sweetener. Interestingly, the two crystalline complexes possess the same main intermolecular interaction sites, except the locations of the acidic proton are different.

Graphical abstract: Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
26 Dec 2015
Accepted
03 Mar 2016
First published
04 Mar 2016

RSC Adv., 2016,6, 26474-26478

Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states

X. Fu, J. Li, L. Wang, B. Wu, X. Xu, Z. Deng and H. Zhang, RSC Adv., 2016, 6, 26474 DOI: 10.1039/C5RA27759K

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