Issue 2, 2016

β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp3)–H bonds using a palladium catalyst

Abstract

An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp3)–H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp3)–C(sp2) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp3)–H functionalization.

Graphical abstract: β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp3)–H bonds using a palladium catalyst

Supplementary files

Article information

Article type
Edge Article
Submitted
14 Oct 2015
Accepted
11 Nov 2015
First published
11 Nov 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 1383-1387

Author version available

β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp)–H bonds using a palladium catalyst

J. Peng, C. Chen and C. Xi, Chem. Sci., 2016, 7, 1383 DOI: 10.1039/C5SC03903G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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