Issue 4, 2016

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Abstract

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein.

Graphical abstract: Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Article information

Article type
Perspective
Submitted
17 Nov 2015
Accepted
26 Jan 2016
First published
29 Jan 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 2492-2500

Author version available

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

S. V. Moradi, W. M. Hussein, P. Varamini, P. Simerska and I. Toth, Chem. Sci., 2016, 7, 2492 DOI: 10.1039/C5SC04392A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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