Issue 26, 2015

Tracking single-particle rotation during macrophage uptake

Abstract

We investigated the rotational dynamics of single microparticles during their internalization by macrophage cells. The microparticles used were triblock patchy particles that display two fluorescent patches on their two poles. The optical anisotropy made it possible to directly visualize and quantify the orientation and rotation of the particles. We show that particles exhibit a mixture of fast and slow rotation as they are uptaken by macrophages and transiently undergo directional rotation during their entry into the cell. The size of the particles and the surface presentation of ligands exerted a negligible influence on this heterogeneity of particle rotation.

Graphical abstract: Tracking single-particle rotation during macrophage uptake

Supplementary files

Article information

Article type
Paper
Submitted
16 Apr 2015
Accepted
02 Jun 2015
First published
10 Jun 2015

Soft Matter, 2015,11, 5346-5352

Tracking single-particle rotation during macrophage uptake

L. Sanchez, P. Patton, S. M. Anthony, Y. Yi and Y. Yu, Soft Matter, 2015, 11, 5346 DOI: 10.1039/C5SM00893J

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