Issue 12, 2015

The photothermal effect of silica–carbon hollow sphere–concanavalin A on liver cancer cells

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers and causes of death by cancer. Concanavalin A (ConA) lectin can specifically bind to the glycoprotein receptors of HCC, which are produced by the aberrant overexpression of liver cancer cells. ConA was used in the current study to conjugate on silica–carbon hollow spheres (SCHSs) and applied in the thermal ablation therapy of liver cancer cell lines under near-infrared (NIR) laser irradiation. We found that the amount of ConA–SCHS complex binding to hepatoma cells was significantly higher than that seen with normal hepatocytes, based on flow cytometric analysis and confocal imaging. Hepatoma cells incubated with ConA–SCHSs were thus more easily killed by the subsequent irradiation with a NIR laser. The results show that the ConA–SCHS complex may enhance the interaction with highly expressed ConA receptors on hepatoma cells, and thus serve as an effective photothermal therapy agent for liver cancer treatment.

Graphical abstract: The photothermal effect of silica–carbon hollow sphere–concanavalin A on liver cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
10 Jan 2015
Accepted
03 Feb 2015
First published
03 Feb 2015

J. Mater. Chem. B, 2015,3, 2447-2454

Author version available

The photothermal effect of silica–carbon hollow sphere–concanavalin A on liver cancer cells

Y. Chen, W. Chiu, J. Chen, C. Chang, L. Hui-Ching Wang, H. Lin and H. Chang, J. Mater. Chem. B, 2015, 3, 2447 DOI: 10.1039/C5TB00056D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements