We demonstrate a strategy for effective radioprotection by chitosan-based long-circulating nanocarriers with radio-protective agents. The stable encapsulation does not restrain its radioprotective capability, and exhibits prolonged retention time in blood with a half-life of ∼10 h, thereby showing more beneficial effects than the pure agent in therapeutic efficacy for irradiated mice.
Y. Zhou, S. Hua, J. Yu, P. Dong, F. Liu and D. Hua, J. Mater. Chem. B, 2015, 3, 2931 DOI: 10.1039/C5TB00063G
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