Issue 28, 2015

Ultra-high relaxivity iron oxide nanoparticles confined in polymer nanospheres for tumor MR imaging

Abstract

Superparamagnetic iron oxide nanoparticles encapsulated in hydrophilic chitosan nanospheres were prepared by nonsolvent-aided counterion complexation completely in an aqueous solution. The T2 relaxation of these hybrid nanospheres in vitro and in vivo was investigated. It was found that the molar transverse relaxivity rate r2 of hybrid nanospheres highly depends upon the payload of iron oxide nanoparticles within hybrid nanospheres. Compared to free iron oxide nanoparticles, the molar transverse relaxivity rate, r2 of hybrid nanospheres shows an approximately 8-fold increase and reaches the maximum of 533 Fe mM−1 s−1. Such a high r2 value is probably associated with the clustering effect of iron oxide nanoparticles, which are confined in the chitosan nanospheres. The in vivo magnetic resonance imaging (MRI) demonstrates that the hybrid nanospheres shorten transverse relaxation time, T2 and significantly decrease the signal intensity of the tumor area, giving rise to high contrast tumor MR imaging at a relatively low dose.

Graphical abstract: Ultra-high relaxivity iron oxide nanoparticles confined in polymer nanospheres for tumor MR imaging

Article information

Article type
Paper
Submitted
01 Apr 2015
Accepted
22 May 2015
First published
28 May 2015

J. Mater. Chem. B, 2015,3, 5702-5710

Author version available

Ultra-high relaxivity iron oxide nanoparticles confined in polymer nanospheres for tumor MR imaging

Y. Lin, S. Wang, Y. Zhang, J. Gao, L. Hong, X. Wang, W. Wu and X. Jiang, J. Mater. Chem. B, 2015, 3, 5702 DOI: 10.1039/C5TB00593K

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