Issue 28, 2015

Electrospun poly(l-lactide-co-caprolactone)–collagen–chitosan vascular graft in a canine femoral artery model

Abstract

Poly(L-lactide-co-caprolactone)–collagen–chitosan (P(LLA-CL)–COL–CS) composite grafts were electrospun in this study. Based on the test results for mechanical properties, biodegradability and in vitro cellular compatibility, the optimal weight ratio of P(LLA-CL) to COL/CS was set as 3 : 1. In vivo study was further performed in a canine femoral artery model. The results showed that the 3 : 1 grafts possessed excellent structural integrity, higher patency rate, better endothelial cell (EC) and smooth muscle cells (SMC) growth, as well as higher levels of gene and protein expression of angiogenesis-related cues than those of grafts based on P(LLA-CL). The findings confirmed that the addition of natural materials, such as collagen and chitosan, could effectively improve endothelialization, SMC incursion into the tunica media, and vascular remodeling for tissue engineering.

Graphical abstract: Electrospun poly(l-lactide-co-caprolactone)–collagen–chitosan vascular graft in a canine femoral artery model

Supplementary files

Article information

Article type
Paper
Submitted
02 Apr 2015
Accepted
04 Jun 2015
First published
04 Jun 2015

J. Mater. Chem. B, 2015,3, 5760-5768

Author version available

Electrospun poly(L-lactide-co-caprolactone)–collagen–chitosan vascular graft in a canine femoral artery model

T. Wu, B. Jiang, Y. Wang, A. Yin, C. Huang, S. Wang and X. Mo, J. Mater. Chem. B, 2015, 3, 5760 DOI: 10.1039/C5TB00599J

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