Issue 46, 2015

Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform

Abstract

Nanocomposites combining the mesoporous iron(III) trimesate MIL-100(Fe) (MIL: Matériaux Institut Lavoisier) and platinum nanoparticles (Pt-NPs) have been used as immobilization matrices of glucose oxidase (GOx). Due to the physico-chemical properties of Pt-NPs (electroactivity) and MIL-100(Fe) (high specific surface area and pore volume, biocompatibility), the resulting GOx–MIL-100(Fe)–PtNP bioelectrode exhibits excellent electrocatalytic performances for glucose detection. This novel glucose biosensor presents a high sensitivity of 71 mA M−1 cm−2 under optimum conditions and a low limit of detection of 5 μM with low response time (<5 s). In contrast, substitution of iron by chromium or aluminum in MIL-100 leads to a much lower sensitivity and higher response time values, suggesting that the iron centres of MIL-100(Fe) may be involved in a synergistic effect which indeed enhances the catalytic oxidation of glucose and biosensor activity. Thus, this work extends the scope of MOF nanoparticles with engineered cores and surface to the field of highly sensitive, durable glucose biosensors.

Graphical abstract: Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform

Supplementary files

Article information

Article type
Paper
Submitted
14 Jul 2015
Accepted
07 Oct 2015
First published
08 Oct 2015

J. Mater. Chem. B, 2015,3, 8983-8992

Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform

S. Patra, T. Hidalgo Crespo, A. Permyakova, C. Sicard, C. Serre, A. Chaussé, N. Steunou and L. Legrand, J. Mater. Chem. B, 2015, 3, 8983 DOI: 10.1039/C5TB01412C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements