Issue 9, 2016

A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

Abstract

Nanoparticles (NPs) with integrated functionalities of targeting, therapy, imaging contrast and biocompatibility have shown promise for application in improved disease diagnosis and therapy. Herein, we report a theranostic agent based on a narrow-bandgap small molecule, benzo[1,2-c;4,5-c′]bis[1,2,5]thiadiazole-4,7-bis(9,9-dioctyl-9H-fluoren-2-yl)thiophene (denoted as BBT-2FT), with the strong absorption of near-infrared (NIR) light. Colloidal nanoparticles composed of BBT-2FT showed a photoacoustic signal intensity ten times higher than that of blood, and high photothermal conversion efficiency (η = 40%) under the irradiation of 808 nm laser light, which killed over 90% of HeLa cells in 10 min.

Graphical abstract: A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
12 Nov 2015
Accepted
25 Jan 2016
First published
25 Jan 2016

J. Mater. Chem. B, 2016,4, 1696-1703

Author version available

A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

S. Huang, P. K. Upputuri, H. Liu, M. Pramanik and M. Wang, J. Mater. Chem. B, 2016, 4, 1696 DOI: 10.1039/C5TB02367J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements