Issue 10, 2016
From the journal:

Analyst

A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells†

Sihang Luo,ab   Yingchao Liu,*c   Feiyi Wang,b   Qiang Fei,b   Ben Shi,b   Jiancai An,b   Chunchang Zhao*b  and  Chen-Ho Tunga  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China

b Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China
E-mail: zhaocchang@ecust.edu.cn

c Department of Neurosurgery, Provincial hospital affiliated to Shandong University, Jinan, China
E-mail: 13805311573@126.com

Abstract

A fluorescent probe for fulfilling a lysosome targeting function in hypoxic tumor cells is reported, wherein azoreductase triggers a dramatic fluorescence enhancement and specific imaging of lysosomes in hypoxic cancer cells.

Graphical abstract: A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells

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Article information

DOI
https://doi.org/10.1039/C6AN00369A
Article type
Communication
Submitted
14 Feb 2016
Accepted
15 Apr 2016
First published
15 Apr 2016

Analyst, 2016,141, 2879-2882

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A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells

S. Luo, Y. Liu, F. Wang, Q. Fei, B. Shi, J. An, C. Zhao and C. Tung, Analyst, 2016, 141, 2879 DOI: 10.1039/C6AN00369A

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