Issue 1, 2017

Determination of silver in soft silicone wound dressings using dodecylbenzene sulfonic acid digestion and inductively coupled plasma optical emission spectroscopy

Abstract

Soft silicones are commonly used as a skin-friendly adhesive in wound care products. To prevent infection, silver (Ag) is frequently incorporated into wound dressings as an antimicrobial agent. Recently, wound dressings with Ag directly incorporated into soft silicone wound/skin contact layers have become commercially available. Thus there is a need for accurate Ag determination in these dressings. In this work the determination of Ag in soft silicones by inductively coupled plasma optical emission spectroscopy is described. This method utilises dodecylbenzene sulfonic acid for the digestion of silicones followed by extraction of Ag with hydrochloric acid (HCl). This method shows excellent accuracy (99–104%) and precision (0.3–4.4% CV) by combining matrix matched standards and internal standardization with indium. A short analysis time of 3 minutes per sample is required and the limit of quantification is 27 μg, corresponding to 540 mg kg−1 for a typical sample weight of 50 mg, which is sufficient to determine the Ag content in commercially available soft silicone wound dressings. The procedure is carried out as an open vessel digestion using a single polypropylene tube which minimizes the need for additional equipment and preparative work.

Graphical abstract: Determination of silver in soft silicone wound dressings using dodecylbenzene sulfonic acid digestion and inductively coupled plasma optical emission spectroscopy

Article information

Article type
Paper
Submitted
08 Aug 2016
Accepted
23 Nov 2016
First published
02 Dec 2016

Anal. Methods, 2017,9, 149-153

Determination of silver in soft silicone wound dressings using dodecylbenzene sulfonic acid digestion and inductively coupled plasma optical emission spectroscopy

L. M. Hallerstig, P. Granath, L. Lindgren and M. Tranberg, Anal. Methods, 2017, 9, 149 DOI: 10.1039/C6AY02230H

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