Issue 7, 2016

In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters

Abstract

Alzheimer's disease (AD) is an irreversible neurodegenerative disease which is difficult to cure. When Alzheimer's disease occurs, the level of zinc ions in the brain changes, and the relevant amount of zinc ions continue decreasing in the cerebrospinal fluid and plasma of Alzheimer's patients with disease exacerbation. In view of these considerations, we have explored a new strategy for the in vivo rapid fluorescence imaging of Alzheimer's disease through target bio-labeling of zinc oxide nanoclusters which were biosynthesized in vivo in the Alzheimer's brain via intravenous injection of zinc gluconate solution. By using three-month-old and six-month-old Alzheimer's model mice as models, our observations demonstrate that biocompatible zinc ions could pass through the blood–brain barrier of the Alzheimer's disease mice and generate fluorescent zinc oxide nanoclusters (ZnO NCs) through biosynthesis, and then the bio-synthesized ZnO NCs could readily accumulate in situ on the hippocampus specific region for the in vivo fluorescent labeling of the affected sites. This study provides a new way for the rapid diagnosis of Alzheimer's disease and may have promising prospects in the effective diagnosis of Alzheimer's disease.

Graphical abstract: In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters

Supplementary files

Article information

Article type
Paper
Submitted
01 Apr 2016
Accepted
11 May 2016
First published
27 May 2016

Biomater. Sci., 2016,4, 1085-1091

In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters

L. Lai, C. Zhao, M. Su, X. Li, X. Liu, H. Jiang, C. Amatore and X. Wang, Biomater. Sci., 2016, 4, 1085 DOI: 10.1039/C6BM00233A

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