A competitive coordination-based CeO2 nanowire–DNA nanosensor: fast and selective detection of hydrogen peroxide in living cells and in vivo

Wen Gao; Xueping Wei; Xuejun Wang; Guanwei Cui; Zhenhua Liu; Bo Tang

doi:10.1039/C6CC00112B

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A competitive coordination-based CeO₂ nanowire–DNA nanosensor: fast and selective detection of hydrogen peroxide in living cells and in vivo†

Wen Gao,^a Xueping Wei,^a Xuejun Wang,^b Guanwei Cui,^a Zhenhua Liu^a and Bo Tang*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn

^b Shandong Center for Disease Control and Prevention, Jinan 250014, P. R. China

Abstract

A competitive coordination-based hydrogen peroxide (H₂O₂) nanosensor is constructed by the assembly of FAM-tagged single-strand (ss) DNA on cerium oxide nanowires (CeO₂ NWs). This fluorescent nanosensor is capable of rapidly and selectively tracking H₂O₂ within living cells, as well as directly visualizing H₂O₂ generated by wound-induced oxidative damage in zebrafish larvae.

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Article information

DOI: https://doi.org/10.1039/C6CC00112B
Article type: Communication
Submitted: 06 Jan 2016
Accepted: 28 Jan 2016
First published: 05 Feb 2016

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Chem. Commun., 2016,52, 3643-3646

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A competitive coordination-based CeO₂ nanowire–DNA nanosensor: fast and selective detection of hydrogen peroxide in living cells and in vivo

W. Gao, X. Wei, X. Wang, G. Cui, Z. Liu and B. Tang, Chem. Commun., 2016, 52, 3643 DOI: 10.1039/C6CC00112B

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