Issue 24, 2016

POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery

Abstract

POEGMA-based disulfide-containing fluorescent probes were designed and synthesized to enable the real-time and quantitative analysis of the (bio)reduction of disulfides within the polymeric backbones in complex redox media and in the presence of cells. This study lights up the way of exploiting bioreduction in the extracellular spaces for the delivery of hydrophobic drugs.

Graphical abstract: POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2016
Accepted
20 Feb 2016
First published
25 Feb 2016

Chem. Commun., 2016,52, 4533-4536

POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery

Y. Ling, J. Ren, T. Li, Y. Zhao and C. Wu, Chem. Commun., 2016, 52, 4533 DOI: 10.1039/C6CC00369A

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