Issue 35, 2016
From the journal:

Chemical Communications

Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine†

Yingle Liu, ORCID logo *a   Ke Zhang,b   Yangen Huang,b   Shen Pan,b   Xiao-Qiang Liu,a   Yi Yang,a   Yan Jianga  and  Xiu-Hua Xu*c  

* Corresponding authors

a School of Chemistry and Pharmaceutical Engineering, Sichuan University of Science & Engineering, 180 Xueyuan Street, Huixing Lu, Zigong, Sichuan 643000, China
E-mail: liuyingleyou@163.com

b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China

c Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China
E-mail: xuxiuhua@sioc.ac.cn

Abstract

An unprecedent reaction of indoline-2,3-diones and (triphenylphosphonio)difluoroacetate (PDFA) afforded novel 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles in moderate to excellent yields. These products could be transformed into other trifluoromethylated oxindole derivatives.

Graphical abstract: Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

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Article information

DOI
https://doi.org/10.1039/C6CC00666C
Article type
Communication
Submitted
26 Jan 2016
Accepted
25 Mar 2016
First published
30 Mar 2016

Chem. Commun., 2016,52, 5969-5972

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Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine

Y. Liu, K. Zhang, Y. Huang, S. Pan, X. Liu, Y. Yang, Y. Jiang and X. Xu, Chem. Commun., 2016, 52, 5969 DOI: 10.1039/C6CC00666C

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