Issue 29, 2016

In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

Abstract

We describe a simple setup for in situ continuous monitoring of vapour-induced transformations of organic solids using a benchtop powder X-ray diffractometer. Proof-of-principle application of this setup to model pharmaceutical cocrystals reveals complex reactivity, transformations of reaction intermediates within minutes, and a simple route to the rarely observed monoclinic form of the pharmaceutical cocrystal of carbamazepine and saccharin.

Graphical abstract: In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

Supplementary files

Article information

Article type
Communication
Submitted
22 Feb 2016
Accepted
11 Mar 2016
First published
14 Mar 2016

Chem. Commun., 2016,52, 5120-5123

In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

I. Huskić, J. Christopherson, K. Užarević and T. Friščić, Chem. Commun., 2016, 52, 5120 DOI: 10.1039/C6CC01583B

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