Issue 44, 2016
From the journal:

Chemical Communications

Functionalizing the glycocalyx of living cells with supramolecular guest ligands for cucurbit[8]uril-mediated assembly†

Emanuela Cavatorta,‡a   Mark L. Verheijden,‡a   Wies van Roosmalen,a   Jens Voskuhl,a   Jurriaan Huskens*a  and  Pascal Jonkheijm*a  

* Corresponding authors

a Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, Department of Science and Technology, University of Twente, P. O. Box 217, Enschede, The Netherlands
E-mail: j.huskens@utwente.nl, p.jonkheijm@utwente.nl

Abstract

Multiple naphthol ligands were installed on the glycocalyx of white blood cells via metabolic labeling and subsequent strain promoted azide–alkyne cycloaddition. Only when cucurbit[8]uril was present to drive the formation of ternary complexes, cells specifically assembled on a methylviologen functionalized supported lipid bilayer through multivalent interactions.

Graphical abstract: Functionalizing the glycocalyx of living cells with supramolecular guest ligands for cucurbit[8]uril-mediated assembly

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Article information

DOI
https://doi.org/10.1039/C6CC01693F
Article type
Communication
Submitted
24 Feb 2016
Accepted
03 May 2016
First published
06 May 2016

Chem. Commun., 2016,52, 7146-7149

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Functionalizing the glycocalyx of living cells with supramolecular guest ligands for cucurbit[8]uril-mediated assembly

E. Cavatorta, M. L. Verheijden, W. van Roosmalen, J. Voskuhl, J. Huskens and P. Jonkheijm, Chem. Commun., 2016, 52, 7146 DOI: 10.1039/C6CC01693F

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