Issue 46, 2016
From the journal:

Chemical Communications

One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid†

Hongzhang Deng,abc   Xuefei Zhao,a   Dongxuan He,abc   Weisheng Guo,b   Keni Yang,b   Anjie Dong*ac  and  Xing-Jie Liang*b  

* Corresponding authors

a Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China
E-mail: ajdong@tju.edu.cn

b CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China

c Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China

Abstract

A new type of membrane fusogenic lipid was prepared to deliver DNA or siRNA into the cytoplasm directly in a fusion-dependent manner in order to bypass the cellular endocytosis to avoid the inefficient escape from the endosome and low transfection efficacy.

Graphical abstract: One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid

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Article information

DOI
https://doi.org/10.1039/C6CC01996J
Article type
Communication
Submitted
06 Mar 2016
Accepted
26 Apr 2016
First published
26 Apr 2016

Chem. Commun., 2016,52, 7406-7408

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One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid

H. Deng, X. Zhao, D. He, W. Guo, K. Yang, A. Dong and X. Liang, Chem. Commun., 2016, 52, 7406 DOI: 10.1039/C6CC01996J

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