Issue 42, 2016

Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

Abstract

We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.

Graphical abstract: Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2016
Accepted
22 Apr 2016
First published
27 Apr 2016

Chem. Commun., 2016,52, 6930-6933

Author version available

Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

A. Manicardi, E. Gyssels, R. Corradini and A. Madder, Chem. Commun., 2016, 52, 6930 DOI: 10.1039/C6CC02062C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements