Issue 40, 2016

Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo

Abstract

Based on the rapid substitution reaction of the Au–S bond by selenol, we designed and synthesized a nanoprobe 5-FAM-peptide-AuNPs for selenol. Real-time imaging shows that this probe together with the molecular probe QCy7-H2O2 is able to simultaneously and differentially monitor the concentrations of selenol and H2O2 in living cells and in vivo.

Graphical abstract: Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo

Supplementary files

Article information

Article type
Communication
Submitted
10 Mar 2016
Accepted
19 Apr 2016
First published
19 Apr 2016

Chem. Commun., 2016,52, 6693-6696

Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and in vivo

X. Liu, B. Hu, R. Cheng, F. Kong, X. Pan, K. Xu and B. Tang, Chem. Commun., 2016, 52, 6693 DOI: 10.1039/C6CC02111E

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