Issue 51, 2016
From the journal:

Chemical Communications

Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy†

Michael D. Lee,a   Matthew L. Dennis,ab   James D. Swarbrick*a  and  Bim Graham*a  

* Corresponding authors

a Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia
E-mail: bim.graham@monash.edu, james.swarbrick@monash.edu

b CSIRO Biosciences Program, Parkville, VIC 3052, Australia

Abstract

Two-armed lanthanide-binding tags induce significant, long-range paramagnetic effects in the NMR spectra of attached proteins. An enantiomeric pair of rigid, two-armed, cyclen-based tags are reported that produce markedly different effects from the same tagging site, allowing for the measurement of complementary paramagnetic restraints for structural studies.

Graphical abstract: Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy

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Article information

DOI
https://doi.org/10.1039/C6CC02325H
Article type
Communication
Submitted
17 Mar 2016
Accepted
26 May 2016
First published
27 May 2016

Chem. Commun., 2016,52, 7954-7957

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Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy

M. D. Lee, M. L. Dennis, J. D. Swarbrick and B. Graham, Chem. Commun., 2016, 52, 7954 DOI: 10.1039/C6CC02325H

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