Issue 61, 2016

Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

Abstract

Auoxo3, a cytotoxic gold(III) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(I) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.

Graphical abstract: Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

Supplementary files

Article information

Article type
Communication
Submitted
23 Mar 2016
Accepted
10 Jun 2016
First published
10 Jun 2016

Chem. Commun., 2016,52, 9518-9521

Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

G. Ferraro, D. M. Monti, A. Amoresano, N. Pontillo, G. Petruk, F. Pane, M. A. Cinellu and A. Merlino, Chem. Commun., 2016, 52, 9518 DOI: 10.1039/C6CC02516A

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