NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells

Yu Zhang; Ting-Ting Shen; Alexander M. Kirillov; Wei-Sheng Liu; Yu Tang

doi:10.1039/C6CC02571D

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NIR light/H₂O₂-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells†

Yu Zhang,^a Ting-Ting Shen,^a Alexander M. Kirillov,^b Wei-Sheng Liu^a and Yu Tang*^a

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: tangyu@lzu.edu.cn

^b Centro de Quimica Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal

Abstract

In this work, smart near-infrared (NIR) light/H₂O₂-triggered and O₂-evolving nanocomposites were designed and applied for efficient production of ¹O₂ by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O₂ generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.

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Article information

DOI: https://doi.org/10.1039/C6CC02571D
Article type: Communication
Submitted: 25 Mar 2016
Accepted: 03 May 2016
First published: 03 May 2016

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Chem. Commun., 2016,52, 7939-7942

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NIR light/H₂O₂-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells

Y. Zhang, T. Shen, A. M. Kirillov, W. Liu and Y. Tang, Chem. Commun., 2016, 52, 7939 DOI: 10.1039/C6CC02571D

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Chemical Communications