Issue 57, 2016
From the journal:

Chemical Communications

A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease†

Guanglei Lv,a   Anyang Sun,*b   Peng Wei,a   Ning Zhang,b   Haichuang Lana  and  Tao Yi*a  

* Corresponding authors

a Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, P. R. China
E-mail: yitao@fudan.edu.cn

b Laboratory of Neurodegenerative Diseases and Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China
E-mail: sunay@sumhs.edu.cn

Abstract

We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Aβ oligomers both in vitro and in vivo. This probe can penetrate the blood brain barrier and specifically target Aβ oligomers in the brains of transgenic mice in models for Alzheimer's disease.

Graphical abstract: A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C6CC02741E
Article type
Communication
Submitted
01 Apr 2016
Accepted
17 Jun 2016
First published
17 Jun 2016

Chem. Commun., 2016,52, 8865-8868

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A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease

G. Lv, A. Sun, P. Wei, N. Zhang, H. Lan and T. Yi, Chem. Commun., 2016, 52, 8865 DOI: 10.1039/C6CC02741E

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