Very broadband diffusion-ordered NMR spectroscopy: 19F DOSY

Jane E. Power; Mohammadali Foroozandeh; Pinelopi Moutzouri; Ralph W. Adams; Mathias Nilsson; Steven R. Coombes; Andrew R. Phillips; Gareth A. Morris

doi:10.1039/C6CC02917E

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Very broadband diffusion-ordered NMR spectroscopy: ¹⁹F DOSY†

Jane E. Power,^a Mohammadali Foroozandeh,^a Pinelopi Moutzouri,^a Ralph W. Adams,

^a Mathias Nilsson,^a Steven R. Coombes,^b Andrew R. Phillips^c and Gareth A. Morris*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
E-mail: g.a.morris@manchester.ac.uk

^b Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, UK

^c Pharmaceutical Sciences, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, UK

Abstract

A new pulse sequence, CHORUS Oneshot, allows measurements of diffusion-ordered spectroscopy (DOSY) spectra over the full chemical shift range of ¹⁹F for the first time. Swept-frequency pulses are used to give very broadband excitation; the sequence is a prototype for a large family of very broadband liquid state NMR methods.

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Article information

DOI: https://doi.org/10.1039/C6CC02917E
Article type: Communication
Submitted: 07 Apr 2016
Accepted: 26 Apr 2016
First published: 26 Apr 2016
This article is Open Access

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Chem. Commun., 2016,52, 6892-6894

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Very broadband diffusion-ordered NMR spectroscopy: ¹⁹F DOSY

J. E. Power, M. Foroozandeh, P. Moutzouri, R. W. Adams, M. Nilsson, S. R. Coombes, A. R. Phillips and G. A. Morris, Chem. Commun., 2016, 52, 6892 DOI: 10.1039/C6CC02917E

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