Palladium-catalysed hydroamidocarbonylation of 1,3-dienes

Abstract

Herein, we report our recent result on the development of the selective catalytic method towards the synthesis of β,γ-unsaturated imides via Pd-catalysed hydroamidocarbonylation of conjugated dienes. Note that this reaction proceeds under acid additive free conditions. Various dienes, including those of high industrial value (e.g. isoprene, 1,3-butadiene), are shown to be compatible with our established method (28 examples, 40–99% yield), which leads to the corresponding β,γ-unsaturated imides in a highly efficient and atom-economic fashion.