Issue 53, 2016
From the journal:

Chemical Communications

A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo†

Xue-Xiang Zhang,‡ab   Hao Wu,‡bc   Peng Li,a   Zong-Jin Qu,ab   Ming-Qian Tand  and  Ke-Li Han*a  

* Corresponding authors

a State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China
E-mail: klhan@dicp.ac.cn
Fax: +86-411-84675584

b University of the Chinese Academy of Sciences, Beijing 100049, P. R. China

c Division of Biotechnology, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China

d National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, P. R. China

Abstract

We have described the design, synthesis, spectroscopy and biological applications of NI–βGal, a versatile fluorescent probe to detect E. coli β-galactosidase in live cells and mice sensitively and directly, which holds great promise for its application in biomedical research such as gene therapy for cancer in the future.

Graphical abstract: A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo

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Article information

DOI
https://doi.org/10.1039/C6CC04373A
Article type
Communication
Submitted
25 May 2016
Accepted
06 Jun 2016
First published
06 Jun 2016

Chem. Commun., 2016,52, 8283-8286

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A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo

X. Zhang, H. Wu, P. Li, Z. Qu, M. Tan and K. Han, Chem. Commun., 2016, 52, 8283 DOI: 10.1039/C6CC04373A

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