Issue 59, 2016
From the journal:

Chemical Communications

A proline-derived transannular N-cap for nucleation of short α-helical peptides†

Yuan Tian,‡a   Dongyuan Wang,‡a   Jingxu Li,a   Chuan Shi,a   Hui Zhao,a   Xiaogang Niub  and  Zigang Li*a  

* Corresponding authors

a School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, China
E-mail: lizg@pkusz.edu.cn

b College of Chemistry and Molecular Engineering, Beijing Nuclear Magnetic Resonance Center, Peking University, Beijing, China

Abstract

We report herein a proline-derived transannular N-cap as a helix nucleating template in diverse bio-related peptide sequences via macrolactamization on resin. This approach takes advantage of synergistic stabilization effects of both N-capping properties of proline and substitution of a main chain hydrogen bond with a covalent bond.

Graphical abstract: A proline-derived transannular N-cap for nucleation of short α-helical peptides

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Article information

DOI
https://doi.org/10.1039/C6CC04672J
Article type
Communication
Submitted
03 Jun 2016
Accepted
22 Jun 2016
First published
22 Jun 2016

Chem. Commun., 2016,52, 9275-9278

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A proline-derived transannular N-cap for nucleation of short α-helical peptides

Y. Tian, D. Wang, J. Li, C. Shi, H. Zhao, X. Niu and Z. Li, Chem. Commun., 2016, 52, 9275 DOI: 10.1039/C6CC04672J

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