Issue 78, 2016

Rhodium/bisphosphine-thiourea-catalyzed enantioselective hydrogenation of α,β-unsaturated N-acylpyrazoles

Abstract

We successfully extended our Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system to asymmetric hydrogenation of α,β-unsaturated N-acylpyrazoles affording products with high yields and excellent enantioselectivities (up to 97% yield, 99% ee). The pyrazole moiety played an important role in providing H-bond acceptor sites, which is critical for achieving high reactivities and enantioselectivities.

Graphical abstract: Rhodium/bisphosphine-thiourea-catalyzed enantioselective hydrogenation of α,β-unsaturated N-acylpyrazoles

Supplementary files

Article information

Article type
Communication
Submitted
15 Jun 2016
Accepted
29 Aug 2016
First published
30 Aug 2016

Chem. Commun., 2016,52, 11677-11680

Rhodium/bisphosphine-thiourea-catalyzed enantioselective hydrogenation of α,β-unsaturated N-acylpyrazoles

P. Li, X. Hu, X. Dong and X. Zhang, Chem. Commun., 2016, 52, 11677 DOI: 10.1039/C6CC04987G

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