Issue 68, 2016
From the journal:

Chemical Communications

Enzyme-mediated polymerization inside engineered protein cages†

Raphael Frey,a   Takahiro Hayashia  and  Donald Hilvert*a  

* Corresponding authors

a Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland
E-mail: hilvert@org.chem.ethz.ch
Fax: +41 44 632 14 86
Tel: +41 44 63 231 76

Abstract

Engineered variants of the capsid-forming enzyme lumazine synthase, AaLS, were used as nanoreactors for an enzyme-mediated polymerization. Oxidation of 3,3-diaminobenzidine (DAB) by the engineered ascorbate peroxidase APEX2 encapsulated in AaLS capsids resulted in templated formation of polyDAB–capsid nanoparticles of homogeneous size and shape.

Graphical abstract: Enzyme-mediated polymerization inside engineered protein cages

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Article information

DOI
https://doi.org/10.1039/C6CC05301G
Article type
Communication
Submitted
25 Jun 2016
Accepted
27 Jul 2016
First published
27 Jul 2016

Chem. Commun., 2016,52, 10423-10426

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Enzyme-mediated polymerization inside engineered protein cages

R. Frey, T. Hayashi and D. Hilvert, Chem. Commun., 2016, 52, 10423 DOI: 10.1039/C6CC05301G

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