Issue 69, 2016
From the journal:

Chemical Communications

Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry†

Javier Ramos-Soriano,‡ab   José J. Reina,‡b   Alfonso Pérez-Sánchez,a   Beatriz M. Illescas,*a   Javier Rojo*b  and  Nazario Martín*ac  

* Corresponding authors

a Departamento de Química Orgánica, Fac. CC. Químicas, Universidad Complutense de Madrid, Av. Complutense s/n, 28040 Madrid, Spain
E-mail: nazmar@ucm.es

b Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC-Universidad de Sevilla, Av. Américo Vespucio 49, 41092 Seville, Spain

c IMDEA-Nanoscience, Campus Cantoblanco, 28049 Madrid, Spain

Abstract

The synthesis of a new highly symmetric hexakis adduct of C60 appended with 12 cyclooctyne moieties has been carried out. This compound has been used for the copper-free strain-promoted cycloaddition reaction to a series of azides with excellent yields. This strategy for the obtention of clicked adducts of [60]fullerene is of special interest for biological applications.

Graphical abstract: Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry

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Article information

DOI
https://doi.org/10.1039/C6CC05484F
Article type
Communication
Submitted
01 Jul 2016
Accepted
20 Jul 2016
First published
20 Jul 2016

Chem. Commun., 2016,52, 10544-10546

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Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry

J. Ramos-Soriano, J. J. Reina, A. Pérez-Sánchez, B. M. Illescas, J. Rojo and N. Martín, Chem. Commun., 2016, 52, 10544 DOI: 10.1039/C6CC05484F

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