Issue 72, 2016

Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles

Abstract

Replication of chiral L- and D-α-(p-tolyl)glycine has been achieved in combination with the asymmetric induction, amplification and multiplication of their own chiral intermediates, L- and D-aminonitriles, in the solid-phase via the Strecker reaction between three achiral components, which is a plausible prebiotic mechanism for amino acid synthesis.

Graphical abstract: Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2016
Accepted
28 Jul 2016
First published
28 Jul 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 10834-10837

Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles

S. Aiba, N. Takamatsu, T. Sasai, Y. Tokunaga and T. Kawasaki, Chem. Commun., 2016, 52, 10834 DOI: 10.1039/C6CC05544C

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