We report on self-assembly of guanosines with aromatic esters at their 5′-position. Depending on the basicity of the 5′-ester either discrete octamers G8·K+I− or hexadecamers G16·3K+3I− are formed. The thermodynamic and kinetic stabilities of the G-quadruplex can be controlled by interlayer hydrogen-bonding and by dispersion interactions on the assembly's periphery.
K. B. Sutyak, P. Y. Zavalij, M. L. Robinson and J. T. Davis, Chem. Commun., 2016, 52, 11112 DOI: 10.1039/C6CC06271G
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