Issue 90, 2016
From the journal:

Chemical Communications

C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams†

Renyi Shi,a   Lijun Lu,a   Hangyu Xie,a   Jingwen Yan,a   Ting Xu,b   Hua Zhang,a   Xiaotian Qi,b   Yu Lan*b  and  Aiwen Lei ORCID logo *ac  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China
E-mail: aiwenlei@whu.edu.cn

b School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, P. R. China
E-mail: lanyu@cqu.edu.cn

c State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China

Abstract

Pd-catalyzed selective amine-oriented C8–H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing group for promoting this process. It represents a straightforward and easy method to access various biologically important benzo[cd]indol-2(1H)-one derivatives.

Graphical abstract: C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams

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Article information

DOI
https://doi.org/10.1039/C6CC06358F
Article type
Communication
Submitted
03 Aug 2016
Accepted
12 Oct 2016
First published
17 Oct 2016

Chem. Commun., 2016,52, 13307-13310

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C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams

R. Shi, L. Lu, H. Xie, J. Yan, T. Xu, H. Zhang, X. Qi, Y. Lan and A. Lei, Chem. Commun., 2016, 52, 13307 DOI: 10.1039/C6CC06358F

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