Issue 77, 2016
From the journal:

Chemical Communications

A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response†

Rong Huang,ab   Bei-Bei Wang,ab   Xing-Ming Si-Tu,ab   Tao Gao,ab   Fang-Fang Wang,ab   Huan He,ab   Xiao-Yang Fan,ab   Feng-Lei Jiang*ab  and  Yi Liu*ab  

* Corresponding authors

a State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: fljiang@whu.edu.cn, yiliuchem@whu.edu.cn
Fax: +86 27 6875 4067
Tel: +86 27 6875 6667

b Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China

Abstract

A highly sensitive and selective Rhodamine B-based fluorescent sensor, RhB-1, for glutathione (GSH) was easily synthesized. An extremely fast detection response time of 10 s, which is the fastest one ever reported, is achieved in aqueous solutions over a wide pH range with large enhancement of emission intensity. The sensor detects GSH in cells and selectively accumulates in lysosomes.

Graphical abstract: A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response

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Article information

DOI
https://doi.org/10.1039/C6CC06750F
Article type
Communication
Submitted
17 Aug 2016
Accepted
26 Aug 2016
First published
30 Aug 2016

Chem. Commun., 2016,52, 11579-11582

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A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response

R. Huang, B. Wang, X. Si-Tu, T. Gao, F. Wang, H. He, X. Fan, F. Jiang and Y. Liu, Chem. Commun., 2016, 52, 11579 DOI: 10.1039/C6CC06750F

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