Issue 1, 2017

Fluorescent glycoprobes: a sweet addition for improved sensing

Abstract

The development of small-molecule fluorescent probes for the detection of ions and biomacromolecules and for cellular and in vivo imaging has been a very active research area. Nevertheless, many problems exist for traditional probes including their poor water solubility, toxicity and the inability to target specific tissues. Because of the enhanced water solubility, biocompatibility and targeting ability for specific cells, there has been an emerging movement to use carbohydrates as either the backbone or as a warhead to decorate conventional fluorescent probes, producing “glycoprobes” with enhanced properties. This feature article provides an overview of recently developed glycoprobes for ion and protein detection as well as targeted (receptor targeting) cellular imaging and theranostics. Here, we summarise the tactics for preparing small molecular glycoprobes and their supramolecular 2D material composites.

Graphical abstract: Fluorescent glycoprobes: a sweet addition for improved sensing

Article information

Article type
Feature Article
Submitted
22 Aug 2016
Accepted
03 Oct 2016
First published
04 Oct 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 82-90

Fluorescent glycoprobes: a sweet addition for improved sensing

X. He, Y. Zang, T. D. James, J. Li, G. Chen and J. Xie, Chem. Commun., 2017, 53, 82 DOI: 10.1039/C6CC06875H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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