Issue 97, 2016

Organocatalytic asymmetric formal arylation of benzofuran-2(3H)-ones with cooperative visible light photocatalysis

Abstract

An organocatalytic asymmetric reaction of benzofuran-2(3H)-ones with naphthoquinones is disclosed. The current method provides a direct way to facilitate arylation of benzofuran-2(3H)-ones in high yields with excellent enantioselectivities. A cooperative visible light photocatalysis with asymmetric hydrogen-bond catalysis has also been developed, thus allowing the more widely available 1-naphthols instead of naphthoquinones to be applied to facilitate the arylation with satisfactory results (up to 95% ee).

Graphical abstract: Organocatalytic asymmetric formal arylation of benzofuran-2(3H)-ones with cooperative visible light photocatalysis

Supplementary files

Article information

Article type
Communication
Submitted
30 Aug 2016
Accepted
25 Oct 2016
First published
25 Oct 2016

Chem. Commun., 2016,52, 13955-13958

Organocatalytic asymmetric formal arylation of benzofuran-2(3H)-ones with cooperative visible light photocatalysis

Y. Liu, J. Li, X. Ye, X. Zhao and Z. Jiang, Chem. Commun., 2016, 52, 13955 DOI: 10.1039/C6CC07105H

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