Issue 90, 2016

Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

Abstract

Natural products are privileged scaffolds due to their high propensity to possess bioactivity. To expedite discovery of thiol-containing compounds, we devised a selective solid-supported reagent for their immobilization, followed by cleavage of a photocleavable linker to yield stable natural product conjugates for direct detection by mass spectrometry. Importantly, the natural products can also be tracelessly released to yield the native structures for chemical and biological evaluation.

Graphical abstract: Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

Supplementary files

Article information

Article type
Communication
Submitted
30 Aug 2016
Accepted
28 Sep 2016
First published
30 Sep 2016

Chem. Commun., 2016,52, 13229-13232

Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

S. L. Capehart and E. E. Carlson, Chem. Commun., 2016, 52, 13229 DOI: 10.1039/C6CC07111B

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