Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF2H-containing heterocycles

Weijun Fu; Xin Han; Mei Zhu; Chen Xu; Zhiqiang Wang; Baoming Ji; Xin-Qi Hao; Mao-Ping Song

doi:10.1039/C6CC07771D

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Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF₂H-containing heterocycles†

Weijun Fu,*^a Xin Han,^b Mei Zhu,^a Chen Xu,^a Zhiqiang Wang,^a Baoming Ji,^a Xin-Qi Hao^b and Mao-Ping Song^b

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* Corresponding authors

^a College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, Henan 471022, China
E-mail: wjfu@lynu.edu.cn

^b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450052, China

Abstract

The visible-light-mediated oxydifluoromethylation of olefinic amides with difluoromethyl sulfones has been explored. This method allows for an efficient and practical synthesis of a variety of CF₂H-containing benzoxazines and oxazolines bearing various functional groups under mild conditions.

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Article information

DOI: https://doi.org/10.1039/C6CC07771D
Article type: Communication
Submitted: 24 Sep 2016
Accepted: 20 Oct 2016
First published: 28 Oct 2016

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Chem. Commun., 2016,52, 13413-13416

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Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF₂H-containing heterocycles

W. Fu, X. Han, M. Zhu, C. Xu, Z. Wang, B. Ji, X. Hao and M. Song, Chem. Commun., 2016, 52, 13413 DOI: 10.1039/C6CC07771D

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Chemical Communications