Issue 5, 2017

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Abstract

The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-charged phospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells.

Graphical abstract: A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Supplementary files

Article information

Article type
Communication
Submitted
28 Sep 2016
Accepted
13 Dec 2016
First published
15 Dec 2016

Chem. Commun., 2017,53, 945-948

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

R. Subiros-Funosas, L. Mendive-Tapia, J. Sot, J. D. Pound, N. Barth, Y. Varela, F. M. Goñi, M. Paterson, C. D. Gregory, F. Albericio, I. Dransfield, R. Lavilla and M. Vendrell, Chem. Commun., 2017, 53, 945 DOI: 10.1039/C6CC07879F

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