Issue 99, 2016
From the journal:

Chemical Communications

Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles†

Zhong-Quan Liu*ab  and  Zejiang Lic  

* Corresponding authors

a School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou 213164, P. R. China
E-mail: liuzhq@lzu.edu.cn

b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

c College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei, P. R. China

Abstract

A first free-radical triggered site-specific cross dehydrogenative coupling reaction of heterocycles with simple nitriles is developed. It allows efficient and facile access to various C-2 cyanoalkylated furans, thiophenes, indoles, and pyrroles. The extremely high selectivities in this case indicate that functionalization of an inert C–H bond could be well-controlled by radical initiation.

Graphical abstract: Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles

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Article information

DOI
https://doi.org/10.1039/C6CC08213K
Article type
Communication
Submitted
12 Oct 2016
Accepted
18 Nov 2016
First published
18 Nov 2016

Chem. Commun., 2016,52, 14278-14281

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Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles

Z. Liu and Z. Li, Chem. Commun., 2016, 52, 14278 DOI: 10.1039/C6CC08213K

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