Multiplex miRNA assay using lanthanide-tagged probes and the duplex-specific nuclease amplification strategy

Shixi Zhang; Rui Liu; Zhi Xing; Sichun Zhang; Xinrong Zhang

doi:10.1039/C6CC08334J

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Multiplex miRNA assay using lanthanide-tagged probes and the duplex-specific nuclease amplification strategy†

Shixi Zhang,^a Rui Liu,

^b Zhi Xing,^a Sichun Zhang*^a and Xinrong Zhang^a

Author affiliations

* Corresponding authors

^a Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing, China
E-mail: sczhang@mail.tsinghua.edu.cn

^b College of Chemistry, Sichuan University, Chengdu, China

Abstract

A multiplex ICP-MS-based miRNA assay with duplex-specific nuclease amplification using bifunctional oligonucleotide probes was proposed. A multiplex assay of miR-141, let-7d, and miR-21 could be achieved simultaneously.

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Article information

DOI: https://doi.org/10.1039/C6CC08334J
Article type: Communication
Submitted: 16 Oct 2016
Accepted: 18 Nov 2016
First published: 18 Nov 2016

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Chem. Commun., 2016,52, 14310-14313

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Multiplex miRNA assay using lanthanide-tagged probes and the duplex-specific nuclease amplification strategy

S. Zhang, R. Liu, Z. Xing, S. Zhang and X. Zhang, Chem. Commun., 2016, 52, 14310 DOI: 10.1039/C6CC08334J

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Chemical Communications

Multiplex miRNA assay using lanthanide-tagged probes and the duplex-specific nuclease amplification strategy†

Abstract

Supplementary files

Article information

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Multiplex miRNA assay using lanthanide-tagged probes and the duplex-specific nuclease amplification strategy

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