Issue 11, 2017

Pd/Cu-Catalyzed aerobic oxidative aromatic C–H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

Abstract

It is important to achieve diverse functionalization of tertiary anilines due to their importance in biological molecules, pharmaceutical, functional materials, and ligands. A straightforward Pd/Cu-catalyzed oxidative C–H bond activation/N-dealkylative carbonylation of tertiary [1,1′-biphenyl]-2-anilines towards the synthesis of various biologically important phenanthridin-6(5H)-ones has been developed. A wide range of functional groups are well tolerated in this transformation. Moreover, O2 is utilized as the terminal oxidant to promote the oxidative carbonylation process.

Graphical abstract: Pd/Cu-Catalyzed aerobic oxidative aromatic C–H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

Supplementary files

Article information

Article type
Communication
Submitted
29 Oct 2016
Accepted
09 Jan 2017
First published
12 Jan 2017

Chem. Commun., 2017,53, 1908-1911

Pd/Cu-Catalyzed aerobic oxidative aromatic C–H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

R. Shi, H. Niu, L. Lu and A. Lei, Chem. Commun., 2017, 53, 1908 DOI: 10.1039/C6CC08701A

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