Issue 3, 2017

Ni(ii)-catalyzed asymmetric addition of arylboronic acids to cyclic imines

Abstract

A Ni(II)-catalyzed asymmetric addition of arylboronic acids to cyclic aldimines and ketimines is reported. Our tropos phosphine-oxazoline biphenyl ligand is crucial for the high catalytic activity, which coordinates to Ni(II) to form a complex with a single axial configuration. The desired chiral amine products could be prepared with excellent yields (up to 99%) and enantioselectivities (up to 99.8%) under mild reaction conditions.

Graphical abstract: Ni(ii)-catalyzed asymmetric addition of arylboronic acids to cyclic imines

Supplementary files

Article information

Article type
Communication
Submitted
01 Nov 2016
Accepted
07 Dec 2016
First published
07 Dec 2016

Chem. Commun., 2017,53, 609-612

Ni(II)-catalyzed asymmetric addition of arylboronic acids to cyclic imines

M. Quan, L. Tang, J. Shen, G. Yang and W. Zhang, Chem. Commun., 2017, 53, 609 DOI: 10.1039/C6CC08759K

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